Short Title:
Lymphostasis Inflammation and Microbial Intolerance
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| National Space Biomedical Research Institute (NSBRI) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Gastrointestinal (GI) health is critical to the maintenance of whole organismal health and disruptions in GI function can have far reaching effects. Previous work suggests that there is a perturbation in the function of the GI system, which has been attributed mostly to microgravity.
- Aim 1: Examine levels of Inflammatory markers and nutritional changes in hind limb unloaded (HU) animals and space-flown animals. We will also measure the lipid distribution/levels, carbohydrate, and nitrogen levels in the stool of HU and space-flown animals.
- Aim 2: Examine antigen and lipid transport from the gut to the mesenteric node in hind limb unloaded animals, and lipid transport/deposition in the gut of space-flown animals and to assess lymphatic function and immune surveillance if might be compromised in the hind limb unloaded model.
- Aim 3: Determine if space flight and HU are capable of inducing changes in the gut microbiome and the host tolerance to it.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
These experiments are designed to determine if there is abnormal nutritional absorption, protein losing enteropathy (PLE) and inflammation in the intestine and if so, what is the probable driving mechanism. It is imperative to establish whether simulated microgravity or space flight induces any baseline inflammation in the intestine, as these factors can affect the ability of the intestine to function properly.
Internal Customers:
None
External Customers:
None