Task Fluid Shift Associated Lymphostasis of the Gut Induces Inflammation and Microbial Intolerance (NSBRI-Cromer) (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Lymphostasis Inflammation and Microbial Intolerance
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Gastrointestinal (GI) health is critical to the maintenance of whole organismal health and disruptions in GI function can have far reaching effects. Previous work suggests that there is a perturbation in the function of the GI system, which has been attributed mostly to microgravity.

  • Aim 1: Examine levels of Inflammatory markers and nutritional changes in hind limb unloaded (HU) animals and space-flown animals. We will also measure the lipid distribution/levels, carbohydrate, and nitrogen levels in the stool of HU and space-flown animals.
  • Aim 2: Examine antigen and lipid transport from the gut to the mesenteric node in hind limb unloaded animals, and lipid transport/deposition in the gut of space-flown animals and to assess lymphatic function and immune surveillance if might be compromised in the hind limb unloaded model.
  • Aim 3: Determine if space flight and HU are capable of inducing changes in the gut microbiome and the host tolerance to it.
Mappings