Task Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: partial-gravity analog in rats
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Rats will be used to evaluate the potential effectiveness of artificial gravity for the prevention of muscle atrophy and weakness and loss of bone using an innovative system for partial unloading that has been developed previously for mice. Musculoskeletal response will be studied during a period of 4 weeks in adult male rats (n=14 / group) during a period of 4 weeks following exposure to different degrees of unloading representing 0.2G, 0.4G, and 0.7G as well as in fully loaded animals. Muscle and bone structure and function will be assessed, histological analyses will be performed, and measurements of muscle contraction, bone mass, microarchitecture and strength will be collected. In addition, serological and tissue molecular analyses will be perfomed to better understand the mechanisms and time course of development of these changes at different degrees of unloading. This work will also allow a more effectively understanding of the relationship between

the development of muscle atrophy and weakness and bone deterioration at varying levels of artificial gravity.


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RiskRisk of Bone Fracture due to Spaceflight-induced Changes to Bone
You are here!TaskMusculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)

RiskRisk Of Early Onset Osteoporosis Due To Spaceflight
You are here!TaskMusculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)

RiskRisk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
You are here!TaskMusculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)