Task Development of a Muscle Adaptation in Space-flight Simulator ("MASS")
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: MASS
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):

DESCOPED and then DEFUNDED due to a shift in strategic planning.

The aim is to develop a multiscale computational model that can predict changes in muscle structure and function in response to both microgravity and in-flight exercise. The modeling approach will provide a cohesive, user-friendly, and open-source framework for computational simulations at different levels of spatial scale, including: dynamic OpenSim simulations at the whole body level; finite-element simulations of muscle tissue; and agent-based simulations of muscle cells that include the biochemical and biomechanical processes that drive individual muscle cell adaptations. This level of integration is necessary because factors at all of these scales influence the degree of muscle atrophy during prolonged spaceflight but they have never been considered in isolation.

Resources (None Listed)