HRR - Task - SANS Integrated Flight Countermeasure Studies

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SANS Integrated Flight Countermeasure Studies

Last Published: 04/20/22 11:43:26 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: TBD

Short Title: SANS Integrated Flight CM

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Planned-Funded - Task expected to be within budget

Procurement Mechanism(s):

Solicited

Aims:

This is a planned flight study to be solicited or directed after completion of the ground based SANS Ground Analog Countermeasure Study.

Resources (Flight)

Flight Resources

Number of Subjects

Deliverables (1)

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:

A validated countermeasure to mitigate or prevent Spaceflight Associated Neuro-ocular Syndrome (SANS).

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-501: Test the finalized combined mechanical/non-mechanical countermeasure in the spaceflight environment (on ISS).

SANS Integrated Flight Countermeasure Studies

Related Tasks (101)

Hindlimb suspension (HS) as an analog model of ocular alterations associated with cephalad fluid shifts: resveratrol as a countermeasure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Pilot study to evaluate a novel non-invasive technology to estimate peripheral and central venous pressure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

rVisual Impairment and Intracranial Pressure Project Data Mining

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals [SD-OCT ANALYSIS/PASS/COMPLETED

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Prospective Observational Study of Ocular Health in ISS Crews (Macias)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

A data mining project to identify cardiovascular related factors that may contribute to changes in visual acuity within the astronaut corps

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Are Medications Involved in Vision and Intracranial Pressure Changes Seen in Spaceflight? [VIIP PHARM/WOTRING]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Development of in-flight fundoscopy

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Fundoscopy Trade Study

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Development of in-flight diagnostic OCT

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Diagnostic OCT Trade Study

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

ICP Tech Search (Innocentive, Yet To Come) COMPLETED

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of Microgravity on Intracranial Pressure [MICROGRAVITY ICP/LEVINE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Analysis of a Clinical Database as a Means to Validate Non-invasive Assessment of Intracranial Pressure Using the Cerebral and Cochlear Fluid Pressure (CCFP) Analyzer [CCFP DATA MINING/EBERT/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Upgrade Visual Acuity Software and In-flight Tonometer

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Non-invasive ICP device purchase & evaluation [VITTAMED ICP DEVICE EVALUATION/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Head-down tilt as a model for intracranial and intraocular pressures, and retinal changes during spaceflight (Fuller)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Pre & Postflight MRV review (central venous congestion) [VIIP MRV/RIASCOS/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Retrospective Pre and postflight measurement of cerebrospinal fluid (CSF) dynamics [MR-ICP CSF DYNAMICS RETROSPECTIVE/ALPERIN]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Brain Gene Expression Signatures from Cerebrospinal Fluid Exosome RNA Profiling [CSF EXOSOME GROUND/ZANELLO]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations Evidence Report

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Microgravity Associated Compartmental Equilibration (Dulchavsky)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Fluid Distribution before, during and after Prolonged Space Flight (Hargens)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution (Roberts)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance (Stenger)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Evaluation of Hindlimb Suspension as a Model to Study Ophthalmic Complications in Microgravity: Ocular Structure and Function and Association with Intracranial Pressure (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound [ULTRASOUND ICP/DENTINGER]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement [NON-INVASIVE ICP GROUND COMPARISON/WILLIAMS/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Association of Diffusion Tensor Imaging Parameters of Optic Tracts and Cerebral White Matter Tracts with Visual Impairment and Structural Changes of the Eyes and Optic Nerves in Long-Duration Microgravity Exposure [DTI/RIASCOS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

A gene expression and histological approach to the study of cerebrospinal fluid production and outflow in rats (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Testing Mechanical Countermeasures for Cephalad Fluid Shifts [MECHANICAL COUNTERMEASURES - MARKETED DEVICES/STRANGMAN]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Venous Congestion Countermeasure Study (Marshall-Goebel)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Microgravity-driven Optic Nerve/Sheath Remodeling Simulator [OPHTHALMIC CHANGES MODELING/ETHIER]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mapping by VESGEN of Blood Vessels in the Human Retina for Improved Understanding of Visual Impairments and Increased Intracranial Pressure (Parsons-Wingerter)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Role of the Cranial Venous Circulation in Microgravity-Associated Visual Changes [CRANIAL VENOUS CIRCULATION/BUCKEY]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of Long Duration Spaceflight on Venous and Arterial Compliance in Astronauts [VASCULAR COMPLIANCE/PLATTS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Preventing Secondary Brain Injury by Early Detection of Cerebral Bleeding and Edema [CEREBROTECH/LEVINSON/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Digital Astronaut: VIIP Modeling

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Assess Glymphatic Changes for Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Evaluation of an Impedance Threshold Device as a Vision Impairment and Intracranial Pressure (VIIP) Countermeasure [IMPEDANCE THRESHOLD COUNTERMEASURE/EBERT]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Validation of a Cephalad Fluid Shift Countermeasures [FLUID SHIFT COUNTERMEASURE/MACIAS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

VIIP and One-Carbon Metabolism: Expanded Polymorphism Evaluation and Polycystic Ovary Syndrome Pilot Study (Smith)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

STOP VIIP Study: Safe and Effective Countermeasures to Reduce Intracranial Pressure and Ameliorate VIIP in Astronauts [STOP VIIP/Levine]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Comparing Globe Distortions Following Head-Down Bed Rest to those Measured in Astronauts in Short and Long-Duration Spaceflights [Thirty-day CO2 Bedrest/ALPERIN/ACTIVE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Clinical Evaluation of the Newest Generation of a Non-Invasive ICP Meter (Vittamed) in Subjects Undergoing Invasive ICP Measurement [VITTAMED 2/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Optical System for Monitoring Net Ocular Blood Flow (Mujat)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Gravitational dose and multi-system physiologic response

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Impact of +Gz and -Gz induced fluid shifts on ocular and cerebral parameters during simulated Orion re-entry.

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (Ethier)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Maturation Task - SANS CM to SCLT/HMTA

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-501: Test the finalized combined mechanical/non-mechanical countermeasure in the spaceflight environment (on ISS).

Eye Vein Pressure Device (Sit)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mechanical and gravitational countermeasures to ocular changes during strict head-down tilt bedrest (Marshall-Goebel)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Exploration Atmosphere Bedrest

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Self-Generated LBNP for Deep-Space Missions (Hargens)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of microgravity on ocular vascular hydrodynamics - ISS (Zawieja)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Investigating Structure and Function of the Eye - ISS (Macias)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest (Bershad)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS Data Integration using IMPALA

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits (Mao)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Markers of Vascular Risks Associated with Spaceflight Associated Neuro-ocular Syndrome - ISS (Hein)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Changes of the optic nerve dura mater in astronauts and SANS (Ethier)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Investigating Long-term Structural and Functional Changes in the Eye and Brain after Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mobile Gravity Suit, An Integrative Countermeasure Device (Petersen)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight (Tavakkoli)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Exercise Countermeasure to Prevent Ocular Structural and Functional Changes in a Terrestrial Model of SANS - Bedrest (Huang)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Lower Body Negative Pressure Device Flight Demo - ISS

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-501: Test the finalized combined mechanical/non-mechanical countermeasure in the spaceflight environment (on ISS).

Mitigating headward fluid shifts and vision impairment with thigh cuffs during spaceflight - ISS

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-501: Test the finalized combined mechanical/non-mechanical countermeasure in the spaceflight environment (on ISS).

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-501: Test the finalized combined mechanical/non-mechanical countermeasure in the spaceflight environment (on ISS).

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Gateway SANS Occupational & Research Monitoring

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Measuring Transcutaneous Partial Pressure of Carbon Dioxide (PCO2) to Estimate Arterial PCO2 during Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS Larger Animal HLS + Radiation Study - Lab

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Ophthalmic and intracranial structural changes in head-down tilt bedrest: potential countermeasures and comparison to SANS findings in astronauts (Martin)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Brain-Related Assessments for Investigating the Neurophysiology of SANS

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Recovery Timeline of Spaceflight-Induced Central Nervous System Changes

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Gateway SANS Research Mini-OCT

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Long-Term Brain Structural and Functional Consequences of Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Exploring Endothelial Function Risk Factors and Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS Combination of Mechanical and Non-Mechanical Countermeasures-Bedrest

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Maturation Task - SANS Standards for maintaining inflight health to OCHMO

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Maturation Task - SANS Standards for Long Term Health to OCHMO

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

The Long-Term Consequences of Spaceflight on Brain and Eye Health

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

B Complex: A Nutraceutical SANS Countermeasure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

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Risk Approach Plans (1)

This task can be found in the following Risk Approach Plans.

SANS Risk Approach plan

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