Task 2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)
Last Published:  07/31/18 09:30:09 AM (Central)
Short Title: CVD Rodent ISS
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:

Focus of this research is the evaluation of the effects of the combined exposures (weightlessness plus radiation) on cardiovascular structure and function.

 

Specific Aims:

  • Aim 1: Utilize a ground-based rodent animal model involving hindlimb suspension as a simulation of weightlessness combined with radiation exposures

  • Aim 2: Evaluate potential oxidative and inflammatory biomarkers as surrogate endpoints and compare with available human data from ISS missions

  • Aim 3: Evaluate effects of combined exposures on disease latency and progression

  • Aim 4: Investigate effects of countermeasures for mitigation of the simulated deep space effects

  • Aim 5: Validate ground analogs with flight cohorts


Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!Task2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!Task2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

RiskRisk of Cardiac Rhythm Problems
You are here!Task2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!Task2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

RiskRisk of Inadequate Nutrition
You are here!Task2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

RiskRisk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
You are here!Task2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)