Task 2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CVD Rodent ISS
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:

Focus of this research is the evaluation of the effects of the combined exposures (weightlessness plus radiation) on cardiovascular structure and function.

 

Specific Aims:

  • Aim 1: Utilize a ground-based rodent animal model involving hindlimb suspension as a simulation of weightlessness combined with radiation exposures

  • Aim 2: Evaluate potential oxidative and inflammatory biomarkers as surrogate endpoints and compare with available human data from ISS missions

  • Aim 3: Evaluate effects of combined exposures on disease latency and progression

  • Aim 4: Investigate effects of countermeasures for mitigation of the simulated deep space effects

  • Aim 5: Validate ground analogs with flight cohorts


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