HRR - Task - Inter-Agency Medical Countermeasures Studies

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Animal radiation study (Radiation Pilot-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Bracelet Investigation (Brazlet Dulchavsky, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Gender Differences in Bedrest: Autonomic and Neuroendocrine Changes and Vascular Responses in Lower and Upper Extremities (Gender Differences-Platts, Completed)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Dose-Rate Effects and Components of Systems Governing Variations in Susceptibility for Carcinogenic and Acute Radiation Risks following Gamma-Ray, Proton, or HZE Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Patterns of Energy Deposition by HZE Particles in Cellular Targets

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Integrated Radiation Analysis and Design Tools

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

Early Markers of Space-Radiation Induced Human Cataractogenesis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Measurements and Transport Phase 2 Physics Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Comparative Analysis of Charged Particle-Induced Autosomal Mutations in Murine Tissues and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Role of high-LET radiation-induced mitotic catastrophe in mutagenesis: implication for carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Telomeric proteins in the radiation/DNA damage response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

DNA Damage Clusters in Human Cell Transformation Induced by Single or Multiple Space Radiation Ion Exposures--Wilson

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High energy proton dose-rate and mixed field effects on neoplastic transformation in vitro

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms for induction of bystander effects by high-energy particles in cells and tissues

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Role of Gap-Junction Communication and Oxidative Metabolism in the Biological Effects of Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Structural Chromosome Aberrations Formed in Response to Changes in Proton Energy and Dose Rate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose-rate effects of protons on the induction of genomic instability in vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

miRNA profiling of radiation response: A systems biology approach to understanding regulation of proton and heavy ion dose effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A Novel Biodosimetry Method

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The mechanism of excess relative risk on carcinogenesis induced by high-LET radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose rate effects on the mechanisms of space radiation induced delayed genomic instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Elucidating the Relationship Between the Effects of Various Radiation Qualities and Cancer Development Processes using Novel Flow-based Assays

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE-induced mammary cancer development processes in murine and "humanized" models, and their influence on radiation quality functions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A mechanistic investigation of space radiation-induced carcinogenesis - NNX12AB88G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radiation and Gliomagenesis: A Sensitive Model System to Evaluate the Tumorigenic Potential of HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radiation quality and the relationship between induced telomere dysfunction and mutagenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Epigenetic effects of radiation on epithelial cell self-renewal

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Sensory Stimulation Augmentation Tools (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Psychomotor Vigilance Test (PVT) on ISS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Objective Detection, Evaluation and Countermeasures for In-flight Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurobehavioral Conditions List for Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Asthenia Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Voice Content Analysis Techwatch

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Integrated Cognitive Assessment: Combining Measurement, System, and Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Prediction of the Onset of Anxiety Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

White Paper on the Onset of Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Meta-Analysis of the effects of ICE environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Evidence Review on Identification of Psychosocial Characteristics in ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Growth and Resilience for Long Duration Exploration Missions(RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Effects of Well-Being on Performance in ICE Environments (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Self-Guided Depression Treatment on Long-Duration Spaceflights

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Asynchronous Behavioral Health Treatment Techniques

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Immune Function Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sleep-Wake Actigraphy and Light Exposure During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Environmental Factors Evidence Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Biomarkers of Individual Vulnerabilities to Sleep Loss and Circadian Desynchronization

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Team Risk Standardized Measures Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Evaluation of Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-Day Study (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optimizing Light for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Blue Light for Enhancing Alertness in Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Feasibility Pilot Study on Acute Biological and Behavioral Responses to the Solid State Lighting Modules for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects (pilot study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individualized Fatigue Meter for Space Exploration (SBIR Phase II)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Survey of On-Orbit Sleep Quality (Sleep Quality Questionnaire)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Phoenix Scout Lander: Countermeasures Testbed for Spaceflight Ground Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

A Comprehensive Fatigue Management Program and an Evaluation of a Photic Countermeasure for Mission Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Impact of Radiation Quality on Cancer Processes in 2D and 3D Esophageal Cell Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

NSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: The contribution of non-targeted effects in HZE cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Space Radiation and Intestinal Tumorigenesis: Risk Assessment and Counter Measure Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

Effects of prolonged exposure to space radiation on carcinogenesis and neuroendocrine differentiation in human prostate models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: NASA Specialized Center of Research on Radiation Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

Integrated experimental and computational study of radiation induced matrix remodeling in a human skin equivalent

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Tissue-specific acute and late molecular surveillance of particle radiation effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Links Between Persistent DNA Damage, Genome Instability, and Aging

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Systematic Identification of Genes and Signal Transduction Pathways Involved in Radio-Adaptive Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Update of the Nuclear Fragmentation Cross Section Code NUCFRG2

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Quantum Multiple Scattering Model of Heavy Ion Fragmentation (QMSFRG)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Epigenetic Control of Radiogenic Damage Processing in C. elegans

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Virtual Reality (VR) Technologies for Enhancing Behavioral Health

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Determination of the magnitude and time course of cardiovascular alterations during a simulated extended stay lunar mission

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Assessing Team Performance in Autonomous Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Harderian Gland Tumorigenesis: Low-Dose-, Low-Dose-Rate-, and LET-Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms of Cell Survival Following Space Radiation-Induced Mitotic Catastrophe: Implications for Cancer Risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

A Novel Biological Countermeasure and Mitigator of High LET-Induced Cancer Progression

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

HZE-induced skin carcinoma: an in-vivo-like multicellular epithelial model system for analysis of radiation quality effects and DSB repair processes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Duke NSCOR: Lung Cancer Risk From HZE Ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Risks Estimates and Mechanisms of Lung Cancer Pathogenesis After Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Mechanisms Underlying the Risk of HZE Particle-Induced Solid Tumor Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Impact of Individual Susceptibility and Previous Radiation Risk for Astronauts

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Two-Hit Model of Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Space Radiation Effects on Genomic and Epigenetic Stability: Influence of Radiation Quality and Genetic Predisposition-NNX13AK70G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dependence of Radiation Quality on Charged Particle-induced Early and Late Damages in Chromosomes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Lee)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Multi-Modal Neurodiagnostic Tool for Stress Monitoring

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sleep Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individualized Behavioral Health Monitoring Tool

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

CogGauge Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Self-Guided Multimedia Stress Management and Resilience Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Characterize Workload on the International Space Station (ISS) (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Fast Neutron Dosimeter for the Space Environment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Artificial Gravity Exposure Effects on Cardiovascularly Deconditioned Women's and Men's Orthostatic Intolerance Limit (Ames AG EPSCoR-Evans, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

In vivo induction of chromosome instability and aberrant patterns of DNA methylation in hematopoietic stem/progenitor cells by heavy ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Characterization of the Tumor Spectrum Arising in HZE Ion Irradiated Outbred Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Synergistic Effects of Bcl2, Cigarette Smoking and Space Radiation on Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

High LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

3D Tissue Models for Study of Intercellular Signaling Stimulated by High Energy Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Targeting protein cross talk signaling as a biological predictor for space radiation cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Android App Incorporating the PVT to deliver individualized Fatigue Risk Management in Commercial Trucking

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Comparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Analysis of Clastogenic Factors in Gamma-Exposed Animals

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Molecular and cellular effects of heavy ion fragmentation due to shielding

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

DNA Damage Responses Induced by HZE Particles In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mouse models approach for intestinal tumorigenesis estimates by space radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of Ocular Cataracts

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Computational Modeling Of Chromosome Aberrations Produced By HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Histone Acetyltransferases and the Cellular Response to DNA Damage

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A role for homologous recombination in complex DSB repair after HZE particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Speech monitoring of cognitive deficits and stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Low Dose Radiation Cataract

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

T-helper Cell Gene Expression and Function in Response to Low Dose and Acute Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radioprotectors and Tumors: Molecular Studies in Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

Comparative Analysis of Fe-Induced Autosomal Mutations in Murine Tissue and Cell Lines

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of Human Skin Responses to Low Radiation Doses and Dose Rates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Contribution of Tissue Level Organization to Genomic Stability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Spectroscopic Dosimeter

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Replacement Lighting for Research and Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Mechanism of Radiation-Induced Alteration of Astrocyte-Neuronal Coupling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR Radiation Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Mathematical Modeling of Circadian/Performance Countermeasures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Model of Circadian Disruption in the Space Environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?

Optical Computer Recognition of Performance Under Stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development of a User Interface for the PVT SelfTest (PST)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Functional Role Of The Betaig-H3 Gene In High-Energy Heavy Ions-Induced Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

Chromatid Painting for Chromosomal Inversion Detection

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE Radiation: Modulation Of Genetic Effects By RNA Interference Of NHEJ

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Mechanisms of HZE Damage and Repair in Human Epithelial Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Methods for Real Time Measurement of Dose and Charged Particle Spectrum

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Deep Space Radiation on Human Hematopoietic Stem and Progenitor Cell Function

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Early Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
	BMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
	BMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?

Fundamental Biological studies of protein phosphorylation profiles after HZE exposure

Common Item(s)