Task Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: ApoE Late CNS/CVD
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
  • Aim 1: investigate late CNS/CVD Effects of Simplified 5-ion Mixed Field Beam (normalized to 500 mGy) GCR IRR in Male & Female AD Tg and WT Mice.

  • Aim 2: investigate Late CNS/CVD Effects of Simplified 5-ion Mixed Field Beam IRR in Male and Female APP/E3 and APP/E4 Tg and WT Mice.

  • Aim 3: investigate Acute and Late CNS and CVD Effects of Simplified 5-ion Mixed Field Beam Space Radiation on Human Cells In Vitro

Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
You are here!TaskSex- and Apo E-specific late CNS and cardiovascular effects of space radiation

RiskRisk of Spaceflight Induced Cardiovascular Disease
You are here!TaskSex- and Apo E-specific late CNS and cardiovascular effects of space radiation