Task Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: CBS Facility/Animal Translation Standards
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed
Aims:
Directed study to determine/develop standardization and recommendations related to animal handling, research facility (e.g., volume, lighting, sound, etc.) & animal/rodent type (species/strains) to increase reliability & validity of animal to human translational research yields by increasing standardization between radiobiological and neurobehavioral methodology, identification and application of genotype to phenotype, biomarkers, and to regional pathophysiology related to operationally-relevant brain performance pathways. From biomarkers to performance measures, it is vital to standardize measurements and tests across PIs for this integrated approach to ensure the reproducibility, reliability, and robustness of tests.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskDetermination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskDetermination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance