Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: CBS Data Mining (Mulavara)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
Literature review and assessment of NASA-funded current and completed research findings relevant to this integrated risk. Identify behavioral and physiological (biomarker) cellular, molecular changes & brain regions linked to specific effects of targeted GCR simulation ions, simulated altered gravity stressor and/or space flight with translational relevance to operational performance measures. Identify Brain Performance Pathway neural circuitry responsible for operationally-relevant behavior characteristics to determine similar neuronal circuits maintaining coherent functions; assess artificial stimulation of the particular network (sensitive to CBS means—radiation, isolation & confinement, altered gravity) that generate predicted responses; and identify biomarkers that influence or act as the carriers of the network activity (neurotransmitters and other biomarkers with messenger activity) that predict the relevant behavioral changes.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskCentral Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskCentral Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining