Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: CBS POL/PEL Standard Update
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed effort to integrate initial research results, compose draft POLs for use in developing PELs.  Assess "synergistic" effects of integtrated risks.  Initial "in progress review" to  gain approval through the required control boards  for needed updates (BRES, HSRB, etc.). The conceptual basis within the CBS Integrated Research plan anticipates the need to approach operationally-relevant performance POLs with an openness in considering how a synergistic effect may result in a decrement of performance that is perhpas not most effectively represented in the same way a PEL represents a cancer risk from space radiation. Since the focus of a Performance Outcome Level does not necessarily reflect “pathology”, the representation to identify “integrated pathways” for the three risks, indicates the need to ensure we understand (and parse out) the potential vs combined effects on operational performance. That performance may not rise to the “pathological-level” associated with “health concerns” only; but rather prior to getting to pathological level of concern, there are likely detectable decrements of operational performance that are of operational concern (e.g., a reaction time that slowed on average by 10% may not be pathological but might be of great concern is a maneuver is required that requires a reaction time closer to 100% of the crewmember’s preflight level of performance).  In addition, individual differences in one’s lifestyle, family history etc. can all play a role in one’s cancer risk due to radiation exposure but these inter-individual differences are seldom, if ever, considered in developing PELs for radiation exposure.
Resources (None Listed)
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskIntegrated CNS/BMed/SM (CBS) POL/PEL Review and Standard Update

RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskIntegrated CNS/BMed/SM (CBS) POL/PEL Review and Standard Update