Task Acute CNS Stress Response, Cross-species Homology Study (NRA)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS Stress Response, Cross-species Homology Study NHPs
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
Research project focused on developing scientifically plausable, heuristic, computational models using Non-Human Primates (NHP) and radiation exposures (both clinical and space relevant,  in combination with other CBS realted spaceflight stressors) in order to assess, characterize and derive and valdiate operationally-relevant  models of performance outcome levels relative to radiation exposures (in combination with other CBS realted spaceflight stressors), dose effects and countermeasures for CBS integrated risk exposures in humans. An important aspect of this effect involves the conceptualization of research that is "reverse translation" in which consideration is given to the specific biological markers with significant operationally-relevant performance consequences are first determined in human models and then applied to an animal model to see if they exist and that they reflect the same performance decrements as evidenced in humans. This approach will facilitate the identification of novel biomarkers linked to different levels of performance (impact by CBS synergistic risks) with the introduction of CBS integrated risk at different stages of mission-relevant performance demands in the animal models. This also offers the potential to identify biomarkers related to the brain performance pathways.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskAcute CNS Stress Response, Cross-species Homology Study (NRA)

RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskAcute CNS Stress Response, Cross-species Homology Study (NRA)