Short Title:
CBS Cortical Reorganization (RFP)
Responsible HRP Element:
Human Factors and Behavioral Performance
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Collaborating Org(s):
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| Human Health Countermeasures (HHC) Element |
| Space Radiation (SR) Element |
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Funding Status:
Planned-Funded - Task expected to be within budget
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Procurement Mechanism(s):
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Aims:
Specific focal impacts on brain regions are important for us to understand since cortical organization reveals a “between-module connectivity” that when disrupted, is associated with widespread cognitive dysfunction. This underscores the importance of conceptualizing Brain Performance Pathways (BPP) and the role of a modular structure in enabling brain processes that support a wide range of operationally-relevant behaviors. This also potentially relates to the putative role of "Cognitive Reserve" and potential for a measures of cortical organization to serve as a "biomarker." This is evidenced by research that demonstrates an “intelligence” relationship that is revealed with cortical organization, with those scoring higher on IQ tests showing smaller functional connectivity changes between “resting state” and “task performance states” (suggesting more efficient adaptation to task demands). Given the different sensitivities of brain tissue to both types and dosages of radiation, stress, and altered gravity, we need to assess the potential role of the connectivity patterns as representative of BPPs to assess differential vulnerabilities to modular networks and just as importantly, determine how a more modular brain network may potentiate CMs (e.g., the potential for up-regulation in neurotrophic factors that have been associated with greater exercise-related changes in brain connectivity).
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
-Identification of specific focal impacts on brain regions and "between-module connectivity" that are linked to operationally-relevant behavior & cognitive functioning.
-A determination of how these connectivity patterns are representative of the BPPs and reflect differential vulnerabilities to brain changes that are linked to performance.
-Assess operational-relevance of the thirteen modules that have been identified in Power et al., 2011: default mode (DMN), fronto-parietal (FP), cingulo-opercular (CO), salience (Sal), dorsal attention (DAN), ventral attention (VAN), auditory (Aud), visual (Vis), memory (Mem), sensory/somatomotor hand (SM-hand), sensory/somatomotor mouth (SM-mouth), subcortical (Subcort) and determine feasibility of assessing linear adaptations that may accrue in connectivity patterns throughout mission, exposure, or adaptation.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None
Category:
Subcategory:
Description:
Internal Customers:
None
External Customers:
None