Task Computational Modeling for CBS Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Computational Modeling for CBS Synergistic/Order Effects of Spaceflight Hazards
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
This CBS Integrated Research topic is proposed to assemble a multidisciplinary team into an “integrated” Virtual NSCOR with multiple research arms that use GCRsim mixed field as the core with experimental design and with translational conceptualizations that leverage the Research Domain Criteria (RDoC) to provide computational model to characterize and predict changes in operationally-relevant Brain Performance Pathways using animal models to assess distinct processes of cognitive and behavioral changes of relevance to operationally-relevant performance, linking neural processes and biomarkers to these constructs in order to assess synergistic and order-effects of radiation exposure (RE), isolation & confinement stress (ICS), and SM (hindlimb unloading), using standardized handling and behavioral tests, brain physiology changes (to include Blood-Brain-Barrier changes), molecular signaling with biomarker changes. This approach is also intended to help develop the framework for performance outcome limits and determine more targeted countermeasures for intervention.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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