Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: CBS CM1 Devel/Validation (Nutrition/Biomarker Signaling)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
This study builds on CM1 Trade Study (above) to provide ground development and validation of CMs to counter synergistic effects on identified risk areas. This study applies the results of the CBS Integrated Risk Trade Study, with those results now serving to guide research heuristics in an effort to  identify and ground-validate the most technically acceptable, feasible and scientifically valid countermeasures from transdisciplinary perspective.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskIdentification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on CNS/BMed/SM (CBS) Risk Areas (NRA)

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskIdentification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on CNS/BMed/SM (CBS) Risk Areas (NRA)

RiskRisk of Inadequate Nutrition
You are here!TaskIdentification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on CNS/BMed/SM (CBS) Risk Areas (NRA)

RiskRisk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
You are here!TaskIdentification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on CNS/BMed/SM (CBS) Risk Areas (NRA)