HRR - Task - MicroHost Countermeasure Validation

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MicroHost Countermeasure Validation

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: TBD

Short Title: Micro CM Validation

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Planned-Funded - Task expected to be within budget

Procurement Mechanism(s):

TBD

Aims:
The preceding planned studies will identify the need and potential countermeasures for microbial control. This work will determine the efficacy of proposed microbiological countermeasures with validation on ISS. The resulting countermeasures will be transferred to operations for implementation on future exploration missions.

Resources (Ground Analog)

Deliverables (1)

Mappings

Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.

Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.

MicroHost Countermeasure Validation

Related Tasks (43)

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.
	Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.

Ground-Based Flight Analogs TBD
Number of Subjects	0