HRR - Task - Countermeasures to Radiation Induced Cardiomyopathy

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Countermeasures to Radiation Induced Cardiomyopathy

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Edwards, John

Short Title: Radiation-induced Cardiomyopathy Countermeasures

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Aim 1. To compare and contrast the efficacy of countermeasures to High-LET exposure

in cultured heart cells.

Aim 2: Compare and contrast the efficacy of druggable molecules in the long-term

management in an animal model of high-LET radiation induced cardiomyopathy.

Resources (None Listed)

Deliverables (2)

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:

1. Identification of several countermeasures which are highly efficacious within the

parameters of the testing protocols.

2. Identification of useful countermeasures that already have FDA approval would place

them at a countermeasure readiness level of 6.

Internal Customers:
None External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

Going forward we do have the technical expertise to do carry out these protocols in a

large animal model such as dog or pig. However the timeframe could prove costly. I

would recommend testing the countermeasures during flight operations using C.

elegans or mice as the next step to move the countermeasures to level 8 and

technology readiness level 7.

A much clearer understanding of the long-term consequences of high-LET on the

pathophysiology of heart failure. The broader implication is that what we learn in this

organ system may apply to other organ systems.

Internal Customers:
None External Customers:
None

Mappings

Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

Countermeasures to Radiation Induced Cardiomyopathy

Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

Countermeasures to Radiation Induced Cardiomyopathy

Risk of Radiation Carcinogenesis

Cancer-501: Identify and translate countermeasures to reduce radiation carcinogenesis and degenerative risks with shared biology.

Countermeasures to Radiation Induced Cardiomyopathy

Risk of Spaceflight Induced Cardiovascular Disease

CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

CVD-201: Select countermeasures and procedures to be tested based on previous objectives.

Countermeasures to Radiation Induced Cardiomyopathy

Related Tasks (260)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease