HRR - Task - Countermeasures to Radiation Induced Cardiomyopathy

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Countermeasures to Radiation Induced Cardiomyopathy

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: Edwards, John

Short Title: Radiation-induced Cardiomyopathy Countermeasures

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Aim 1. To compare and contrast the efficacy of countermeasures to High-LET exposure

in cultured heart cells.

Aim 2: Compare and contrast the efficacy of druggable molecules in the long-term

management in an animal model of high-LET radiation induced cardiomyopathy.

Resources (None Listed)

Deliverables (2)

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:

1. Identification of several countermeasures which are highly efficacious within the

parameters of the testing protocols.

2. Identification of useful countermeasures that already have FDA approval would place

them at a countermeasure readiness level of 6.

Internal Customers:
None External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

Going forward we do have the technical expertise to do carry out these protocols in a

large animal model such as dog or pig. However the timeframe could prove costly. I

would recommend testing the countermeasures during flight operations using C.

elegans or mice as the next step to move the countermeasures to level 8 and

technology readiness level 7.

A much clearer understanding of the long-term consequences of high-LET on the

pathophysiology of heart failure. The broader implication is that what we learn in this

organ system may apply to other organ systems.

Internal Customers:
None External Customers:
None

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

CV-201: Select countermeasures and procedures to be tested based on previous objectives.

Countermeasures to Radiation Induced Cardiomyopathy

Risk of Radiation Carcinogenesis

Cancer-502: Systematically identify safe and effective countermeasures to reduce radiation carcinogenesis.

Countermeasures to Radiation Induced Cardiomyopathy

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes