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Task CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
Last Published:  07/30/21 01:05:34 PM (Central)
Task Book: Entry
Principal Investigator: Ronca, April
Short Title: CBS VNSCOR #2: Effects of GCRsim/HU/ICE on Immune, Performance with Dietary CM Dev (Ronca)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
The overall goal is to minimize risks in both male and female astronauts that are associated with long-term, deep space missions. This will be achieved to generate research results on biomarkers, brain morphology and function, performance pathways, and functional behavioral performance impairments, necessary inputs for computational human health risk models of combined space exposures. The successful completion of this work will provide a clear understanding of synergistic interactions between space environment factors in relation to crew health and performance during extended missions beyond the Van Allen belts.                                                                     
Aim 1: Determine dose dependence of acute ‘Five-Ion GCR Simulation’ exposure for immune, brain and behavioral performance responses in crew age-matched adult male and female mice. 
Aim 2: Determine effects of acute ‘Five-Ion GCR Simulation’ exposure singly and in combination with simulated microgravity and social isolation, on immune and nervous system responses in crew age-matched male and female mice mimicking deep space missions.
Aim 3: Determine efficacy of the dietary antioxidant, Nicotinamide Mononucleotide (NMN) in reversing immune, brain and behavioral/cognitive performance effects after acute ‘Five-Ion GCR Simulation’ exposure in socially isolated, IR and simulated microgravity exposed male and female mice, mimicking deep space missions.
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Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskCBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskCBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy