Task Neuro-Vestibular Examination During and After Spaceflight (Clement)
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: CIPHER Vestibular Health - ISS
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
CIPHER Ocular Alignment was combined with the CIPHER Vestibular Health study.

Clement Aims:
  • Examine the head position relative to the body and, if tilted look for the presence of an ocular tilt reaction.
  • Determine the subjective nonvisual vertical using the test of the finger. A deviation of the subjective vertical occurs in more than 90 % of all acute unilateral peripheral and central vestibular disorders.
  • Examine the subject for nystagmus when the gaze is straight-ahead or directed right, left, up, and down. Frenzel lenses help to differentiate between a peripheral vestibular spontaneous nystagmus that can be suppressed by visual fixation and a central fixation nystagmus that is present during fixation.
  • Perform positioning maneuver to determine if there is a positioning nystagmus or positioning vertigo, and also to differentiate between a BPPV and a central positional or positioning nystagmus.
  • Examine three different types of eye movements (smooth pursuit, saccades, gaze-holding function) for central eye movement disorders such as saccadic smooth pursuit, gaze-evoked nystagmus, disorder of saccades as well as impaired visual fixation suppression of the VOR. If patients with acute vertigo have central ocular motor disorders, this suggests a central origin.
  • Perform the head-impulse test as well as slow active head rotation addressing the question of a unilateral or bilateral functional deficit of the VOR.
  • Perform whole body rotation and whole-body translation to evaluate whether the subjective perception of motion by the semicircular canals and otoliths is accurate.

Shelhamer Aims:

  • Performance of otolith testing and refinement of procedures in an appropriate analog. Identification of any changes due solely to confinement and close quarters.
  • Crew training.
  • Performance in ISS flights of various durations.
  • Characterization of temporal trends.
  • Comparison of otolith measures with posture and locomotion measures in SM.