Task MinION Viral Detection
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: MinION
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Exploration Medical Capability (ExMC) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:
1. Develop flight compatible sample processing protocols using technology already onboard ISS (or compatible with Gateway) to enable MinION to assay virus DNA in saliva samples.

2. Validate the developed technology against the terrestrial standard assay. The standard is the qPCR assay which has been used for several ISS investigations. This will be accomplished for each relevant virus, via parallel analysis of saliva samples spiked with increasing concentrations of virus DNA

3. Conducts a population survey of at least 20 'normal' subjects. Since shedding of latent herpesviruses is minimal in healthy control subjects, parallel testing may also be performed for higher incidence subjects or patients, as samples are available via our existing suite of ground and flight investigations. This should be permissible as for each parent study, the determination of virus DNA was contained in the original approved proposal.
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