HRR - Task - Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

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Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Tahimic, Candice

Short Title: Cardiovascular responses to simulated spaceflight

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Human Health Countermeasures (HHC) Element

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:
Aim 1. Determine radiation dose-dependence of measures of cardiovascular performance in crew age-matched female and male mice in an acute ‘five-ion GCR simulation’ exposure model.

Aim 2. Determine effects of acute ‘five-ion GCR simulation’ exposure singly and in combination with simulated microgravity on cardiovascular performance measures in crew age-matched male and female mice, mimicking deep space missions.

Aim 3. Determine whether cardiovascular changes induced by GCR or in combination with HU correlate with specific and measurable behavioral, neuromotor and immune outcomes.

Resources (Other)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Study results may enable risk characterization.

Internal Customers:
Human Health Countermeasures
Space Radiation
External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

CVD-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.