Task Bacillus spore probiotics: evaluation of survival and efficacy after exposure to deep-space radiation simulating long-duration human exploration missions
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Bacillus Spore Probiotics-NSRL
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Using the NASA Space Radiation Laboratory (NSRL) at Brookhaven, NY, we propose to evaluate the survival and efficacy of Bacillus spore probiotics vs. traditional probiotic formulations following exposure to simulated Galactic Cosmic Rays (GCRSim) and Solar Particle Events (SPESim) expected to be encountered during NASA Design Reference Missions (DRMs) lasting up to 3 years. Specific aims include: A. Select appropriate freeze-dried, prepackaged probiotic formulations to test. B. Expose samples at NSRL to GCRSim and SPESim at dosages representative of 1, 2, and 3-year DRMs, in parallel with matched lab controls and transport controls. C. Measure viability and efficacy of all samples vs. exposure dose and compare data from exposed vs. control samples. 
Mappings