Task Conditions of Toll like receptors system of the human innate immunity cells during long-term isolations
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: SIRIUS 2020
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:
1. Investigate the effect of isolation for 8 months at the Russian NEK spaceflight vehiclesimulation on immune dysregulation consisting of cellular function, salivary cytokine profiles, and basic peripheral leukocyte distribution.

2. Investigate the effect of NEK deployment on the reactivation and shedding of latent herpesviruses.

3. Correlate all findings with the Russian assessment of novel innate immunity parameters, to derive a comprehensive assessment of the effect of prolonged isolation on human immunity and associated clinical risks.

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