Short Title:
Immune Dysfunction-NEK Sirius-21
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
1. Investigate the effect of isolation for 8 months at the Russian NEK spaceflight vehiclesimulation on immune dysregulation consisting of cellular function, salivary cytokine profiles,
and basic peripheral leukocyte distribution.
2. Investigate the effect of NEK deployment on the reactivation and shedding of latent
herpesviruses.
3. Correlate all findings with the Russian assessment of novel innate immunity parameters, to derive a
comprehensive assessment of the effect of prolonged isolation on human immunity and associated clinical
risks.
Ground Analog Resources
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Ground-Based Flight Analogs
- Controlled Research Analog, Long Duration (4 months or more) – isolated and confined with spaceflight mission scenario [e.g., NEK/Russian Chamber]
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| Number of Subjects
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6
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Category:
Study Results
Subcategory:
Customer Requested Study or Analysis
Description:
This study will
validate the Russian analog using flight validated measures provided by NASA. The novel
aspects of the study may also yield new mechanistic associations that can shed light on the
causes of stress-associated immune alterations.
Internal Customers:
None
External Customers:
None