Task Spaceflight-Induced Immune System Dysregulation and Microgravity-Associated Alterations in Microbial Virulence – Infectious Disease Risk for Astronauts
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Host Pathogen – Immune Response
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:

Specific Aim 1:  Profile the synergistic relationship between spaceflight analogue-altered bacterial virulence characteristics and spaceflight analogue-altered immune cell function. Alterations in immune cell responses will be evaluated when human primary immune cells are challenged with pathogens in normal and spaceflight analogue growth conditions. 

 

Specific Aim 2:  Profile antimicrobial efficacy for astronauts participating in spaceflight via challenge with spaceflight analogue cultured bacterial pathogens. Primary immune cells from astronauts will be profiled before, during, and post-flight to identify alterations in host response to pathogens in normal and spaceflight analogue conditions.

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