Task Effects of Low Dose Radiation and Radiation Countermeasures on Infection by Spaceflight Analogue Cultured Salmonella using 3-D Biomimetic Human Tissue Models
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Radiation Effects on Salmonella
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
Aims: 1. Characterize the impact of spaceflight-analogue culture on the ability of S.
Typhimurium to infect 3-D biomimetic intestinal tissue models before and after exposure to low
dose radiation. 2. Evaluate the ability of the radioprotective compound, EC-18, to protect 3-D
intestinal models from low dose radiation, S. Typhimurium infection, and the cumulative impact
of these stressors.
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