Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
Specific Aim #1
Determine genetic variants in AGBRESA bedrest subjects as was determined for VaPER bedrest
subjects. We will assess the number of risk alleles compared with the degree of optic disc
edema, which will be estimated as the ΔTRT (total retinal thickness measured in images acquired with optical coherence tomography) during and after bed rest.
Specific Aim #2
Measure urinary glycocalyx degradation products from bed rest subjects and assess the
appearance of these markers with the magnitude of ΔTRT.