Task Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Bone strength recovery
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Addressed the observed "discordant recovery dynamic" reported for astronaut data (Lang et al., JBMR 21:1224, 2006) by characterizing bone mass, bone mineral density (BMD), and bone strength relationships after HU and during various periods of recovery.
  2. Examined multiple mission scenarios using HU, recovery for a period, and then a second HU exposure.
  3. Followed the two-exposure protocol but with exercise (both aerobic and resistive) added during the recovery period.

Integration/Unique Aspects: Proximal tibia micro-CT:  results were generated from a collaboration with another HRP-funded investigator Dr. Stefan Judex at Stony Brook University. The data provided results with much higher resolution and greater insight into the details of the effects of hindlimb unloading and recovery upon the proximal tibia metaphysis, including both trabecular bone and the cortical shell.

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