Task Rapid measurements of bone loss using tracer-less calcium isotope analysis of blood and urine (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Calcium Isotope Study
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Determine how quickly changes in skeletal loading produces detectable changes in urinary and blood Ca isotope composition
  2. Begin to estimate how these changes vary between individuals
  3. Resolve diurnal changes and other variations in urinary and blood Ca isotope composition., we will be able to
  4. Reconstruct the isotopic composition of each subjects’ dietary Ca on a meal by meal basis (by measuring the isotopic composition of all dietary items containing significant Ca and obtaining the detailed records of what each subject ate)
  5. Disentangle the dietary signal in urinary and blood Ca isotope composition from the endogenous physiological signal that reflects changes in bone mineral balance.
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