Short Title:
Integrated Immune
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Completed - Task completed and produced a deliverable
|
Procurement Mechanism(s):
|
|
Aims:
There are no procedures currently in place to monitor immune function or its effect on crew health. Immune dysregulation has been demonstrated to occur during spaceflight, yet little in-flight immune data has been generated to assess whether or not this may be a clinical problem. This SMO will assess the clinical risks resulting from the adverse effects of space flight on the human immune system and will validate a flight-compatible immune monitoring strategy. The correlation between in-flight immunity, physiological stress and a measurable clinical outcome (viral reactivation) will be determined for long- vs. short-duration space flight.
-
The objective of this Supplemental Medical Objective (SMO) is 1) to develop and validate an immune monitoring strategy consistent with operational flight requirements and constraints.
Integration/Unique Aspects: Supports AEH 14
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
A report of baseline data characterizing certain aspects of adaptive immunity and herpes virus reactivation during spaceflight was generated during the Integrated Immune and Immuno flight studies, which assessed leukocyte distribution, T cell function, cytokine production profiles for adaptive immune cells (T cells, etc.) along with herpesvirus reactivation. The deliverable will be a final report contributing to gap closure by providing risk quantification.
Data from this study will also be used to provide additional knowledge of host responses in relation to for microbial dose-response characteristics that will be used to determine future research.
Internal Customers:
None
External Customers:
None
Category:
Standard
Subcategory:
Update
Description:
A report containing specific assays will be determined by Immune SRP inputs, relevant NASA board inputs, the solicitation process, peer review process, and final approval.
Data from this study will also be used to provide additional knowledge of host responses in relation to for microbial dose-response characteristics that will be used to determine future research.
Internal Customers:
None
External Customers:
None