Task Incidence of Latent Virus Shedding During Space Flight-DSO 493 (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Latent Virus
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

Shuttle-based study investigating the frequency of latent virus reactivation, latent virus shedding, and clinical disease after exposure to the physical, physiological, and psychological stressors associated with space flight.

Study Summary:
The studies, we found no effects attributed to gender, age, or flight experience of participating astronauts. Given the findings, these viral and immune studies must be repeated on longer ISS missions to determine if the findings in these studies are temporary or do the effects become greater with longer stays in space.  The major accomplishments (products) of DSOs 493 and 498 are documented in 23 peer-reviewed manuscripts published in a variety of well-respected journals.  Manuscripts cited in this report are archived with the Project and are available for the Element and  Program as needed.

• Recommended future studies or gap(s):
Based on the data from these studies, the project suggests the need for future investigations.  Additional ground based countermeasures studies need to be initiated focused on the suppression of viral reactivation and mitigation of the suppressed innate immune system seen in these studies.  Data from the Integrated Immune flight study that is currently in progress will be vital to characterize the risks and persistence of immune dysregulation in-flight and determine the need for additional future studies.  
1. The PIs also suggest the need for the evaluation of shelf-life/stability studies for antiviral drugs during space flight.
2. The project does not recommend any new gaps at this time.  Once more data regarding the Integrated Immune flight study is available, a gap assessment will be performed and new gaps will be suggested if needed at that time.

Integration/Unique Aspects: TBD
Resources (None Listed)