Task Development of Methods/Technologies for Medication Stability and Shelf-life (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Medication Stability
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:

Analyze 9 medications that were returned in numbers sufficient for analysis (at least 40 units each). These medications include several of the most heavily used by our crewmembers: 2 sleep aids, 2 antihistamines/decongestants, 3 pain relievers, an antidiarrheal and an alertness medication. All of these medications expired between February and June 2012. The Clinical Pharmacy has records of their lot numbers, purchase dates, launch dates, and for those medications that were repackaged, repackaging dates. There are no control samples available, which is a significant drawback. Notwithstanding, we suggest that analysis should be conducted using the HPLC/MS methods described in the United States Pharmacopeia for each of these medications to measure the amount of intact active ingredient in each medication, identify degradation products and measure their amounts as well. Although without ground controls, we cannot answer the question of differences in flight-ageing compared to ground-ageing. We think valuable information can still be gained from these analyses. A rapid determination of the safety and efficacy of these 9 heavily-used medications soon after storage on the ISS would be very informative. It would also help us determine if there is a need for additional research.


Integration/Unique Aspects: Collaboration with clinical Pharmacy

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