Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: SR Risk Assessment-Cucinotta
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):
Directed
Aims:
  • Specific Aim A: To facilitate the integration of space radiobiology research results into improved models of BR radiation risk projections.
  • Specific Aim B: To complete the cancer risk uncertainty analysis factors to be used for near-term mission planning (trade studies), and to update these as new radiobiological data sets become available.
  • Specific Aim C: To develop descriptive and predictive models of modifications to biochemical pathways known likely to be causative of cancer risk.
  • Specific Aim D: To integrate or develop new data and models of DNA damage, transmissible chromosomal aberration including translocation, insertions, terminal deletion including telomere loss, and other aberrations related to chromosomal instability or cancer initiation, incorporating applications to the simulations in Specific Aim C.
  • Specific Aim E: To perform a comprehensive assessment of available acute radiation risk projection models, and to develop simulation software of acute risk for mission design assessments.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
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RiskRisk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs)
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RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
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RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
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RiskRisk of Radiation Carcinogenesis
GapCancer 03: How can experimental models of carcinogenesis be applied to reduce the uncertainties in radiation quality effects from SPE’s and GCR, including effects on tumor spectrum, burden, latency and progression (e.g., tumor aggression and metastatic potential)?
GapCancer 04: How can models of cancer risk be applied to reduce the uncertainties in dose-rate dependence of risks from SPE's and GCR?
GapCancer 05: How can models of cancer risk be applied to reduce the uncertainties in individual radiation sensitivity including genetic and epigenetic factors from SPE and GCR?
GapCancer 06: How can models of cancer risk be applied to reduce the uncertainties in the age and sex dependence of cancer risks from SPE's and GCR?
GapCancer 07: How can systems biology approaches be used to integrate research on the molecular, cellular, and tissue mechanisms of radiation damage to improve the prediction of the risk of cancer and to evaluate the effectiveness of countermeasures? How can epidemiology data and scaling factors support this approach?
GapCancer 11: What are the most effective shielding approaches to mitigate cancer risks?
GapCancer 12: What quantitative models, numerical methods, and experimental data are needed to accurately describe the primary space radiation environment and transport through spacecraft materials and tissue to evaluate dose composition in critical organs for mission relevant radiation environments (ISS, Free-space, Lunar, or Mars)?
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta