Task Space Radiation Risk Assessment Project-Cucinotta
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: SR Risk Assessment-Cucinotta
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):
Directed
Aims:
  • Specific Aim A: To facilitate the integration of space radiobiology research results into improved models of BR radiation risk projections.
  • Specific Aim B: To complete the cancer risk uncertainty analysis factors to be used for near-term mission planning (trade studies), and to update these as new radiobiological data sets become available.
  • Specific Aim C: To develop descriptive and predictive models of modifications to biochemical pathways known likely to be causative of cancer risk.
  • Specific Aim D: To integrate or develop new data and models of DNA damage, transmissible chromosomal aberration including translocation, insertions, terminal deletion including telomere loss, and other aberrations related to chromosomal instability or cancer initiation, incorporating applications to the simulations in Specific Aim C.
  • Specific Aim E: To perform a comprehensive assessment of available acute radiation risk projection models, and to develop simulation software of acute risk for mission design assessments.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
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RiskRisk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs)
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RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
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RiskRisk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
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RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
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RiskRisk of Radiation Carcinogenesis
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