Short Title:
2,3-D Skin
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
We propose to irradiate 2D [cell monolayers] and 3D [capillary-like cell structures] with Fe ions at 1GeV with doses where a bystander effect may apply [< 0.1 Gy] to doses where multiple traversals are expected [up to 1Gy]. We will compare responses to low LET X-rays and to alpha particles at the same LET as the Fe ions, where delta rays are less likely to be influential. Chromosomal changes using G2-PCC`s and state of the art m-FISH, micronuclei, apoptosis and cell-cell, cell-matrix interacting proteins will be quantified.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
None
External Customers:
None