Short Title:
Epithelial Renewal
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Using a three-dimensional cell culture system that supports tissue-like behavior of human breast cells, we will: 1) determine the effects of ionization density and dose on the frequency of self-renewal versus differentiation, 2) identify biochemical pathways that show persistent changes as functions of ionization density and dose, and 3) use genetic manipulations to test the mechanistic involvement of discrete pathway components in persistent radiation quality effects.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual and Final Reports
Internal Customers:
None
External Customers:
None