Task Physiologically-Based Modeling of Sleep-Wake Scheduling and the Effects of Pharmaceuticals (NSBRI Postdoctoral Fellowship) (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Modeling Sleep/Meds/Wake
Responsible HRP Element: Behavioral Health and Performance
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
1.Develop a combined model of sleep/wake and circadian rhythms
2. Incorporate the effects of pharmaceuticals: achieve a working model of the phase-shifting effects of melatonin, and intend to next include the hypnotic effects of melatonin. Once this is complete, the model will be validated against forced desynchrony data in which subjects were administered melatonin or placebo. Similar methodologies can then be used to model the effects of other drugs, including caffeine and modafinil (since BWH also has forced desynchrony data for both of these).
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