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Task NSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Task Book: Entry
Principal Investigator: Minna, John
Short Title: Lung Cancer
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

1. Genetic and epigenetic changes in human bronchial epithelial cells following exposure to HZE particle irradiation

2. Effect of HZE particles on DNA damage-sensing and repair pathways in human lung epithelial and fibroblast cells

3. Effect of HZE particle irradiation on functional progression of human lung cancer at the cellular and organotypic level

4. Effects of HZE particles on the development of lung cancer in vivo in novel mouse models

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskNSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure
RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskNSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure
RiskRisk of Radiation Carcinogenesis
You are here!TaskNSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure