HRR - Task - Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

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Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Boothman, David

Short Title: TGF-Beta

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Department of Energy (DoE)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:

This work focused on the mechanisms by which TGF-β1 can over-come p53 suppression and describes the discovery that Klotho, an agent important in aging, can suppress TGF-β1-induction of IGF-1-sCLU expression.

Resources (None Listed)

Deliverables (1)

Mappings

Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors

Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

Risk of Radiation Carcinogenesis

Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis