Short Title:
Mitochondrial Oxidants
Responsible HRP Element:
Space Radiation
Collaborating Org(s):
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Department of Energy (DoE) |
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Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
- Determine if cells with mutations in succinate dehydrogenase (SDH) subunits C and D (SDHC and SDHD in mitochondrial complex II) demonstrate increases in steady-state levels of reactive oxygen species (ROS; O2 and H2O2) as well as demonstrating increased sensitivity to low dose/low LET radiation (?10 cGy) in vitro.
- Determine if specific mitochondrially-derived ROS contributed to increases sensitivity to low dose/low LET radiation in cells containing mutations in SDH subunits in vitro.
- Determine if a causal relationship exists between persistent increases in mitochondrial ROS production, alterations in electron transport chain proteins, and genomic instability in the progeny of irradiated cells.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual and Final Reports
Internal Customers:
None
External Customers:
None