HRR - Task - Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

Gender Differences in Bedrest: Autonomic and Neuroendocrine Changes and Vascular Responses in Lower and Upper Extremities (Gender Differences-Platts, Completed)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose-Rate Effects and Components of Systems Governing Variations in Susceptibility for Carcinogenic and Acute Radiation Risks following Gamma-Ray, Proton, or HZE Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Patterns of Energy Deposition by HZE Particles in Cellular Targets

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Integrated Radiation Analysis and Design Tools

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Measurements and Transport Phase 2 Physics Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Comparative Analysis of Charged Particle-Induced Autosomal Mutations in Murine Tissues and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Role of high-LET radiation-induced mitotic catastrophe in mutagenesis: implication for carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Telomeric proteins in the radiation/DNA damage response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

DNA Damage Clusters in Human Cell Transformation Induced by Single or Multiple Space Radiation Ion Exposures--Wilson

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

High energy proton dose-rate and mixed field effects on neoplastic transformation in vitro

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms for induction of bystander effects by high-energy particles in cells and tissues

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Role of Gap-Junction Communication and Oxidative Metabolism in the Biological Effects of Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Structural Chromosome Aberrations Formed in Response to Changes in Proton Energy and Dose Rate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Dose-rate effects of protons on the induction of genomic instability in vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

miRNA profiling of radiation response: A systems biology approach to understanding regulation of proton and heavy ion dose effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

A Novel Biodosimetry Method

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

The mechanism of excess relative risk on carcinogenesis induced by high-LET radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Dose rate effects on the mechanisms of space radiation induced delayed genomic instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Elucidating the Relationship Between the Effects of Various Radiation Qualities and Cancer Development Processes using Novel Flow-based Assays

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

HZE-induced mammary cancer development processes in murine and "humanized" models, and their influence on radiation quality functions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A mechanistic investigation of space radiation-induced carcinogenesis - NNX12AB88G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Radiation and Gliomagenesis: A Sensitive Model System to Evaluate the Tumorigenic Potential of HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Radiation quality and the relationship between induced telomere dysfunction and mutagenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Epigenetic effects of radiation on epithelial cell self-renewal

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Impact of Radiation Quality on Cancer Processes in 2D and 3D Esophageal Cell Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: The contribution of non-targeted effects in HZE cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NSCOR: Space Radiation and Intestinal Tumorigenesis: Risk Assessment and Counter Measure Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Effects of prolonged exposure to space radiation on carcinogenesis and neuroendocrine differentiation in human prostate models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

NSCOR: NASA Specialized Center of Research on Radiation Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Integrated experimental and computational study of radiation induced matrix remodeling in a human skin equivalent

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Tissue-specific acute and late molecular surveillance of particle radiation effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Links Between Persistent DNA Damage, Genome Instability, and Aging

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Systematic Identification of Genes and Signal Transduction Pathways Involved in Radio-Adaptive Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Update of the Nuclear Fragmentation Cross Section Code NUCFRG2

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Quantum Multiple Scattering Model of Heavy Ion Fragmentation (QMSFRG)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Harderian Gland Tumorigenesis: Low-Dose-, Low-Dose-Rate-, and LET-Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Mechanisms of Cell Survival Following Space Radiation-Induced Mitotic Catastrophe: Implications for Cancer Risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

A Novel Biological Countermeasure and Mitigator of High LET-Induced Cancer Progression

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

HZE-induced skin carcinoma: an in-vivo-like multicellular epithelial model system for analysis of radiation quality effects and DSB repair processes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Duke NSCOR: Lung Cancer Risk From HZE Ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NSCOR: Risks Estimates and Mechanisms of Lung Cancer Pathogenesis After Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NSCOR: Mechanisms Underlying the Risk of HZE Particle-Induced Solid Tumor Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Impact of Individual Susceptibility and Previous Radiation Risk for Astronauts

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation Effects on Genomic and Epigenetic Stability: Influence of Radiation Quality and Genetic Predisposition-NNX13AK70G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Dependence of Radiation Quality on Charged Particle-induced Early and Late Damages in Chromosomes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Fast Neutron Dosimeter for the Space Environment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

In vivo induction of chromosome instability and aberrant patterns of DNA methylation in hematopoietic stem/progenitor cells by heavy ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Characterization of the Tumor Spectrum Arising in HZE Ion Irradiated Outbred Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Synergistic Effects of Bcl2, Cigarette Smoking and Space Radiation on Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

High LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

3D Tissue Models for Study of Intercellular Signaling Stimulated by High Energy Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Targeting protein cross talk signaling as a biological predictor for space radiation cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Comparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Analysis of Clastogenic Factors in Gamma-Exposed Animals

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Molecular and cellular effects of heavy ion fragmentation due to shielding

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

DNA Damage Responses Induced by HZE Particles In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mouse models approach for intestinal tumorigenesis estimates by space radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Computational Modeling Of Chromosome Aberrations Produced By HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Histone Acetyltransferases and the Cellular Response to DNA Damage

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A role for homologous recombination in complex DSB repair after HZE particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

T-helper Cell Gene Expression and Function in Response to Low Dose and Acute Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Radioprotectors and Tumors: Molecular Studies in Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Comparative Analysis of Fe-Induced Autosomal Mutations in Murine Tissue and Cell Lines

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms of Human Skin Responses to Low Radiation Doses and Dose Rates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Mechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

The Contribution of Tissue Level Organization to Genomic Stability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Spectroscopic Dosimeter

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanism of Radiation-Induced Alteration of Astrocyte-Neuronal Coupling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR Radiation Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Functional Role Of The Betaig-H3 Gene In High-Energy Heavy Ions-Induced Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Chromatid Painting for Chromosomal Inversion Detection

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

HZE Radiation: Modulation Of Genetic Effects By RNA Interference Of NHEJ

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Mechanisms of HZE Damage and Repair in Human Epithelial Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Methods for Real Time Measurement of Dose and Charged Particle Spectrum

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Deep Space Radiation on Human Hematopoietic Stem and Progenitor Cell Function

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Early Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Fundamental Biological studies of protein phosphorylation profiles after HZE exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis--NNX08BA54G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Cytogenetic Study Of Heavy Ion-Induced Chromosomal Damage In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NEXGEN Approaches to Chromatid Painting

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells - NNX12AH07G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

Impact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

High-LET Radiation, Reproductive Hormones and Chronic Inflammation: An Integrated Approach to Carcinogenesis Risk Estimate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

A Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

The Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

HZE Radiation Effects on Malignant Progression in Human Epithelial Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanistic Study of the Risk of Low Doses of HZE Particles on Human Cell Pre-Malignant Transformation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanism of Clustered DNA Double-strand Break Repair in Response to HZE Particles in Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Mouse Glioma Models to Estimate Cancer Risks from HZE Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects-NNX11AK26G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Charged Particle Effects on the Ovary

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Defining the role of miR-182 in HZE-Induced Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

The Effect of High LET Radiation on Differentiation and Tumorigenesis in the Human Hematopoietic System: Modeling in vitro and in vivo for Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Contribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo-NNX14AC97G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

The Contribution of Delta Rays to the Chromosome Aberration Dose Response in Human Cells Irradiated with HZE Particles of Different Energy but the Same LET

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Oxidative Stress and the Cancer Risk of Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Molecular characterization of transmissible chromosome aberrations produced by ions of intermediate and high atomic number

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Exosomes and secretory factors as mediators of non-targeted effects of HZE particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Induction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Radiation-induced apoptosis avoidance and colon tumorigenesis: Epigenetic regulation in adult stem cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Space Radiation Risk Assessment Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

NASA Specialized Center of Research on Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Million Worker and Veteran Study

Common Item(s)
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Simulation of GCR-Induced Harderian Gland and Lung Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Blood-based multi-scale model for cancer risk from GCR in genetically diverse populations

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

GCR Simulator Validation Studies with Human and Mouse Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanistic Analysis of Particle Radiation-Induced Carcinogenesis Using Validated Mouse Glioma Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Mouse Models of Cancer Risk and Prevention from Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mars 600/900 Simulation I: Large Animal Chronic Studies

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Functional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

An Integrated Framework for Characterization of the Noncoding Genome and Epigenome in Astronauts (Mason)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Center for Medical Countermeasures II – Cross Risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Center for Medical Countermeasures I - Cancer

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

2022 NSCOR-CVD/Late CNS: Impact of Combined Spaceflight Stressors

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mars 600/900 Simulation II: Large Animal Chronic Studies

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Computational Model Prediction & Biological Validation using Simplified Mixed Field Exposures for the Development of a GCR Reference

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Physical and Biological Modulators of Space Radiation Carcinogenesis: Mechanistically - Based Model Development for Space Radiation Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Biophysics Phase 1

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Tissue Sharing Project-Effects of space radiation on the cardiac mitochondrial stress response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Galactic Cosmic Ray Simulator and Mitigation Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

GCR Simulation Dose Rate Studies

Common Item(s)
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Contracted Study CM Validation I (Cancer)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Multi-Model Ensemble Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Inter-Agency Medical Countermeasures Studies

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Contracted Study CM Validation II (Cross Risk)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of Sex-Specific Differences in Lung Cancer Radiation Risks and Recommendations for Use in Transfer Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Multi-model Ensemble Risk Assessment Maturation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.

Protracted exposure to NASA's GCR-Simulator: Cytogenetic validation and beam time optimization

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Imaging and Serum Biomarkers to Predict and Identify Early Cardiac Injury from Radiation Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Research Review: Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System: Monitoring & Countermeasures Performance Pathways

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

Predictive Biomarkers for Space Radiation Induced Cancer and Cardiovascular Injury Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.

Gamma-tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Countermeasures against adverse effects of space radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Countermeasures to Radiation Induced Cardiomyopathy

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis