Short Title:
Epigenetic C. elegans
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
This task is focussed directly on identifying the genes and pathways that regulate non-targeted damage formation. The high genetic homology between C. elegans and mammalian gene networks should enable predictions of homologous signaling pathways that are operational in mammals, including humans. This should, in turn, improve the understanding of the role of non-targeted effects in the low radiation dose environment and suggest mitigation strategies.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence on role of individual sensitivity and intercellular communication in radiation response, in support of CNS Gap 3 closure.
Internal Customers:
None
External Customers:
None