Task Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: DNA Repair
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
In the present proposal, we introduce an in vitro model of neural progenitors (neurospheres), which is derive from the brain of mouse embryo from neurodegenerative transgenic mice to study the detrimental effects of space radiation at the mechanistic level. Using this biological model, we will study DNA damage repair and apoptosis of proliferating and differentiated neural progenitor exposed to low dose of high charge and energy nuclei and protons.
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