Task Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Systemic Inflammation
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
we will explore the effects of protons and mixed particle radiation, at doses and fluences expected during space travel, in the brain and lung as well as the systemic circulation of mice. Dose and time dependent alteration in inflammatory indices will be correlated with brain and lung degenerative changes, including failure of hippocampal neurogenesis and alterations in hippocampal dependent learning. We will also explore whether space radiation influences Alzheimer's disease pathogenesis using a unique transgenic mouse model and lung inflammation following challenge with inhaled lipopolysaccharide.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskLocal CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskLocal CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure