Short Title:
Oxidative Stress CNS
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
Our proposal is focused on analyzing the effects of space radiation on these critical populations of multipotent neural stem and precursor cells. We have developed the technology to isolate and grow these cells in culture and will use a variety of techniques to analyze how cells exposed to space radiation change. We will monitor the time course of oxidative stress in these cells and how that depends on the dose, the dose rate and type of radiation applied. We will determine how radiation-induced oxidative stress impacts cellular proliferation, signaling between cells, cell fate and survival.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of the role of radiation induced oxidative stress in acute CNS responses to space radiation exposure. This data will provide mechanistic insights in support of CNS gap 1 closure.
Internal Customers:
None
External Customers:
None