Task Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Oxidative Stress CNS
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Our proposal is focused on analyzing the effects of space radiation on these critical populations of multipotent neural stem and precursor cells. We have developed the technology to isolate and grow these cells in culture and will use a variety of techniques to analyze how cells exposed to space radiation change. We will monitor the time course of oxidative stress in these cells and how that depends on the dose, the dose rate and type of radiation applied. We will determine how radiation-induced oxidative stress impacts cellular proliferation, signaling between cells, cell fate and survival.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskOxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskOxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei