Last Published:  04/20/22 11:43:20 AM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Closed
Closure Rationale
Sufficient knowledge exists with respect to the impact of lifestyle, environmental, and dietary factors on the renal stone formation process in spaceflight. Computational models that predict the likelihood of renal stone formation during spaceflight have been developed and validated. ExMC has no plans for new research or work on this gap. Any new information discovered through HHC's food/nutrition work can be integrated into the computational models.
Closure Documentation:
No Closure Documentation Available

Initial State of Gap: Lifestyle, environmental, and dietary factors all greatly affect renal stone risk. Crewmembers who have an increased risk before space flight and then are exposed to microgravity with concomitant bone loss, hypercalciuria, increased urinary sodium, and decreased urinary output may have a further increased risk of renal stone formation during space flight.

Interim steps: 

    1. Renal stone risk profiles related to dietary intake in flight studies: Nutrition SMO, MedB8.1 (Medical Requirement 8.1), and Space Biochemistry Profile study and determine whether there are relationships.
    2. Evaluate past Pro K data and ongoing Integrated Nutrition Countermeasure study dietary intake data in light of renal stone risk profiles.
    3. Identify and quantify most critical dietary patterns for renal stone risk during spaceflight.
    4. Evaluate existing and prospective potassium citrate usage in relationship to renal stone risk profiles. 
    5. Steps 1-4 will be repeated yearly.  The degree of gap closure will increase each year to completion at the end of ISS – crewmembers will be continuously monitored for dietary intake and the presence of renal stones through the end of ISS]

Approach: Evaluate data from: Pro K, Integrated Nutrition Countermeasure study, Nutrition SMO, Space Biochemistry Profile, and MedB8.1 as well as potassium citrate usage data and monitoring of renal stone incidence.

Target for Closure
Determine whether dietary intake patterns can predict or affect renal stone risk. 
Risk Risk of Renal Stone Formation
Risk Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
You are here! Gap N13: Can renal stone risk be decreased using nutritional countermeasures?

Multi-Disciplinary Research Plans

No Documentation Available