Gap CBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
Last Published:  07/31/19 10:05:30 AM (Central)
Responsible Element: Space Radiation (SR)
Status: Open
Description

Initial State of Gap:

Research approaches are establishing the molecular basis of CNS reactions to HZE nuclei exposure.  Since projection based on scaling to human data as done for cancer risk is not possible, a systems biology approach for individual CNS adverse changes may be needed to form a basis for animal to human extrapolation, and will rely on understanding of molecular and physiological changes in the CNS caused by space radiation and how these changes relate to acute CNS adverse outcomes.         

 

Approach:

 Research approaches are establishing the molecular and physiological basis of CNS reactions to HZE nuclei exposure. Since projection based on scaling to human data as done for cancer risk is not possible, a systems biology approach for individual CNS risks may be needed to form a basis for animal to human extrapolation. This approach will rely on understanding of molecular and physiological changes in the CNS caused by space radiation. Intermediate CNS models of important pathways and processes that contribute to CNS risks including synapse dysfunction, impaired neurogenesis, neurodegeneration, neuro-inflammation, etc. will be generated and developed into a model for CNS risk assessment.

Interim Steps:

  • Define risk domains and appropriate metrics that encompass performance decrements of concern (e.g. cognitive and executive function, attention deficits, neuropsychological, neurobehavioral, circadian rhythms, reaction time, motor skills, etc.)
  • Develop intermediate CNS models of important outcome pathways and processes that contribute to CNS risks, including synaptic dysfunction, impaired neurogenesis, neurodegeneration, neuro-inflammation, etc.
  • Combine CNS process models to create model for Acute CNS risk assessment
  • Model validation and documentation

       
Target for Closure
  • Organize CNS reactions to radiation exposure into adverse outcome pathway(s) related to known diseases or conditions of impaired performance and link to biomarkers at molecular, cellular, tissue levels of organization.
  • Development and validation of a model for acute CNS risk assessment from space radiation exposure.
Mappings
Risk Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
Risk Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here! Gap CBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
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Documentation:
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