Gap CBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
Last Published:  07/31/19 10:05:30 AM (Central)
Responsible Element: Space Radiation (SR)
Status: Open
Description

Initial State of Gap:

The combined effect of space radiation exposure with other spaceflight factors on acute and late CNS adverse functional changes and neurodegenerative disease risks are unknown. Sleep disruption can result in reduced cognition and attention as well as impaired memory. High pCO2 and fluid shifts (altered gravity response) can result in altered vascular regulation affecting all organs, including CNS. Stress (including social stress) can impair neurogenesis and immune function. Thus multiple interacting factors leading to impairment of performance in humans may share mechanisms known to be altered by radiation exposure in animal models. It is important to determine whether these factors, in fact, interact with radiation exposure and to quantify the magnitude of the interaction(s).

Approach:

The primary hazards from radiation on the CNS depend on mission location and duration, solar conditions, individual sensitivity, sex, and age at exposure. Secondary hazards include altered gravity, hostile/closed Environment, distance from Earth and isolation. The Space Radiation Element will evaluate research results in collaboration with other HRP Elements to understand secondary hazards as they contribute to psychological and physical stress or modified behavior (affect), sleep deficiency, altered circadian rhythm, hypercapnea, chronic inflammation and altered immune, endocrine and metabolic function as possible modifiers of CNS risks from space radiation. The impact of combined spaceflight stressors on acute and late CNS outcome measures underlying risks will be assessed through ground based, peer-reviewed research using appropriate cell and animal models and validated biomarker panels with extended duration GCR simulations. Current research being performed under the HRP integrated research plan will be used to inform cross-disciplinary approaches in future solicitations.

 

Interim Steps:

  • Determine neuropsychological domains of modulation, associated adverse outcome pathways, and rank order of space flight stressors to determine optimal research approach and appropriate models.
  • Use validated biomarker panels to assess impact of combined spaceflight stressors on acute CNS outcome measures using GCR simulations with dose protraction/fractionation.
  • Use validated biomarker panels to assess impact of combined spaceflight stressors on late CNS outcome measures using extended duration GCR simulations
  • NCRP reviews on spaceflight synergistic risk to the CNS
  • CNS risk assessment model update to incorporate research results on possible synergistic effects

 


Target for Closure
  • Identify spaceflight stressors that impact cognitive and behavioral performance with input from the Behavioral Health and Performance Element (BHP).
  • Relate/incorporate findings from BHP element to outcomes elicited by radiation exposure. Identify overlap of adverse outcome pathways and underlying mechanisms.
  • Impact of combined spaceflight stressors on acute and late CNS adverse outcome measures from space radiation exposure quantified and CNS risk models modified as appropriate.

Related Gap:

BMED3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

 

Mappings
Risk Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
Risk Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here! Gap CBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
Active
Completed
Planned-Funded

Documentation:
No Documentation Available