​ NASA Logo Human Research Roadmap HRP Exploration Data
Home | HRP Goals and Objectives | HRP Architecture | HRP Organizational Structure | Acronyms | Reviews | Help
{1}
##LOC[OK]##
{1}
##LOC[OK]## ##LOC[Cancel]##
{1}
##LOC[OK]## ##LOC[Cancel]##
Evidence MDRP Risks Gaps Tasks Reports
Explore Search
Gap SANS1: We do not know the etiological mechanisms and contributing risk factors for ocular structural and functional changes seen in-flight and postflight.
This Gap was split into the following Gaps:
SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.
SANS-202: Determine if genetic/metabolic/anatomic dispositions and biomarkers, and sex differences have a contributing role in the development of ocular manifestations.
SANS-203: Determine if radiation has a contributing role in the development of ocular manifestations.
SANS-204: Determine if sleep/glymphatics has a contributing role in the development of ocular manifestations.
SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.
SANS-102: Determine the relationship between the fluid-shifts induced ocular changes and fluid shifts in the CNS, including whether elevated intracranial pressure or brain edema play a role.
SANS-104: Determine whether ocular manifestations can be induced by fluid shifts in rodents and whether this model can be used for more detailed mechanistic insights.

Split Rationale
No rationale available.
Next
Previous
This gap can be found in the following Risk Approach Plans.

{1}
##LOC[OK]##
{1}
##LOC[OK]## ##LOC[Cancel]##
{1}
##LOC[OK]## ##LOC[Cancel]##
​ NASA Developer:  Daniel Febus Responsible NASA Official:  Susan Torney Contact HRP for a 508 compliant PDF Budgets, Strategic Plans, and Accountability Reports Equal Employment Opportunity Data Posted Pursuant to the No Fear Act Information-Dissemination Policies and Inventories Freedom of Information Act President's Management Agenda Privacy Policy & Important Notices Inspector General Hotline Contact HRP Human Health and Performance DIR Johnson Space Center USA.gov ExpectMore.gov