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SANS1: We do not know the etiological mechanisms and contributing risk factors for ocular structural and functional changes seen in-flight and postflight.
This Gap was split into the following Gaps:
SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.
SANS-202: Determine if genetic/metabolic/anatomic dispositions and biomarkers, and sex differences have a contributing role in the development of ocular manifestations.
SANS-203: Determine if radiation has a contributing role in the development of ocular manifestations.
SANS-204: Determine if sleep/glymphatics has a contributing role in the development of ocular manifestations.
SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.
SANS-102: Determine the relationship between the fluid-shifts induced ocular changes and fluid shifts in the CNS, including whether elevated intracranial pressure or brain edema play a role.
SANS-104: Determine whether ocular manifestations can be induced by fluid shifts in rodents and whether this model can be used for more detailed mechanistic insights.
Split Rationale
No rationale available.
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This gap can be found in the following Risk Approach Plans.
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Developer: Daniel Febus
Responsible NASA Official: Susan Torney
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