HRR - Gap - Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

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Sleep Gap 2: We need to understand the contribution of sleep loss, circadian desynchronization, extended wakefulness and work overload, on individual health (physical and behavioral), team functioning, and performance (including operational performance), for spaceflight.

This Gap was split into the following Gaps:

Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

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