Gap Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.
Last Published:  11/23/20 11:55:10 AM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Description
Present state of knowledge: Terrestrial evidence suggest clear connections between the microbiome and human health and wellness, including such aspects as mood and behavior, and non-infectious based physiological effects such as inflammation and its potential effects in promoting cardiovascular disease. Current flight experiment data indicate alterations in microbial virulence and other characteristics during spaceflight, however, the relationship between these changes to the microbiome and non-infection aspects of astronaut physiology, health, and performance is almost unstudied.

Research approach:
Current studies that are collecting mood/behavior/cognition as well as microbiome data include Food Physiology (a HERA study has been completed, and a flight study is currently underway), and Spaceflight Standard Measures. Additional solicited and directed studies to be considered. A portion of this work is under the purview of HRP’s Human Factors and Behavioral Performance (HFBP) Element, and inter-Element collaboration will enable to form a comprehensive understanding of this gap.

Target for Closure
Likelihood and consequence data to understand the risk and identify whether there is a need for countermeasures.
Mappings
Risk Risk of Adverse Health Effects Due to Host-Microorganism Interactions
You are here! Gap Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.
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Documentation:
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