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Immune
Tasks
Flight Immune CM Validation
IM-403: Test, optimize and validate stress reduction techniques as preventive and mitigative immune dysfunction countermeasures.
Last Published:
07/30/21 01:05:31 PM (Central)
Responsible Element:
Human Health Countermeasures (HHC)
Status:
Open
Description
Present state of knowledge:
It is well established that stress has a profoundly negative impact on immunity in general, and on the prognosis for certain terrestrial diseases. The practice of stress relieving techniques is therefore beginning to move into mainstream medicine, to augment more traditional pharmacological interventions. Anecdotally, several recent ISS astronauts have practiced a defined stress relieving protocol onboard ISS and reported benefits. These techniques have therefore been incorporated into the suggested interdisciplinary countermeasures protocol for deep space missions.
Research approach:
Several HRP-funded efforts are underway or in planning phases, and in this area close collaboration is expected between the Human Health Countermeasures (HHC) Element and the Human Factors Behavioral Health (HFBP) Element. An upcoming study funded by the Vermont Space Grant Consortium in collaboration with HRP will explore how hypothalamic pituitary adrenal (HPA) axis activation during times of stress impacts immune competence, potentially leading to latent herpesvirus reactivation and replication. This study will utilize a virtual reality headset-based stress relieving protocol that may be applicable for deep space missions. A ground analog-based study has been initiated in the HERA isolation facility utilizing guided imagery added to analog subjects’ exercise sessions. A study is being planned to take place in the Antarctic Palmer Station that will evaluate an integrated immune countermeasure including stress-reduction measures. An ISS flight study to evaluate the beneficial effects of stress reduction techniques on immune system dysfunction is planned as well.
Target for Closure
Validated stress-reducing countermeasures for prevention/mitigation of immune dysfunction.
Mappings
Risk of Adverse Health Event Due to Altered Immune Response
IM-403: Test, optimize and validate stress reduction techniques as preventive and mitigative immune dysfunction countermeasures.
Planned-Funded
Immune Countermeasures Validation - Flight
Task Book:
Entry Unavailable
Principal Investigator:
Crucian, Brian
Short Title:
Flight Immune CM Validation
Responsible HRP Element:
Human Health Countermeasures
Collaborating Org(s):
Funding Status:
Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed
Solicited
Aims:
Multiple lines of evidence indicate that immune dysregulation exists during spaceflight. The mid-point Integrated Immune data indicate that this phenomenon persists during long-duration spaceflight. Should the data indicate that countermeasures development be required, such development would first occur using ground- analogs.
1. This study placeholder is for in-flight validation of the developed countermeasures. Such validation should occur, using the ISS platform, prior to the initiation of exploration-class deep space missions.
Integration/Unique Aspects: TBD
Resources
(
Flight
)
Flight Resources
Number of Subjects
10
Deliverables (1)
Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
A report characterizing the validation of the notional previously developed countermeasure(s)( if the need of countermeasure is evident) .
Internal Customers:
Human Health Countermeasures
External Customers:
None
Is a Customer-Supplier Agreement (CSA) Required?
No
Multi-Disciplinary Research Plans
Documentation:
No Documentation Available
Related Gaps (11)
IM7: It is necessary to correlate the observed effects of spaceflight-associated immune system dysregulation with known terrestrial clinical conditions.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
Immune Countermeasures Validation - Flight
IM-102: Evaluate the effects of altered atmospheric conditions such as elevated CO2 levels or mildly hypoxic exploration atmosphere on immune dysfunction.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-103: Evaluate for novel endogenous viral reactivation
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-104: Evaluate immune dysfunction on missions greater than six months.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
Immune Countermeasures Validation - Flight
IM-105: Identify immune biomarkers that correlate with known spaceflight-related immune dysfunction and immune outcomes, as a first step in designing in-flight monitoring paradigms.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-201: Based on immune dysfunction biomarkers identified in Scientific Objective 1, identify, develop, and implement in-flight immune function monitoring tools for support of research during Gateway, Lunar, and Mars missions.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-301: Identify appropriate ground-based analogs to spaceflight-induced immune dysfunction to enable ground validation of preventive/mitigative countermeasures and derive mechanistic insights.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-402: Test, optimize and validate pharmacological preventive/mitigative countermeasures.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
IM-501: Test the finalized, integrated, multi-component immune countermeasure in flight.
Common Item(s)
Risk of Adverse Health Event Due to Altered Immune Response
Immune Countermeasures Validation - Flight
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Risk Approach Plans (1)
This gap can be found in the following Risk Approach Plans.
Immune Risk Approach plan
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Responsible NASA Official: Susan Torney
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