Last Published:  07/30/20 02:45:13 PM (Central)
Responsible Element: Human Health Countermeasures (HHC)
Status: Open
Present state of knowledge: Various countermeasures can reverse the acute headward fluid shift to varying degrees, but the time course, magnitude of effect, and ability to maintain the fluid shift reversal for prolonged periods of time are unknown. In addition, it is unknown if combining multiple mechanical countermeasures will provide a greater benefit than a single countermeasure.

Research approach: In a laboratory setting, using postures that have been determined to result in the same magnitude of headward fluid shift as that seen during spaceflight, collect data from a variety of promising mechanical and exercise interventions, alone and in combination, for an integrated or standalone mechanical countermeasure that can reverse - and maintain reversed - 0-G induced fluid shifts. Mechanical countermeasures of interest include but are not limited to: lower body negative pressure (LBNP), Impedance Threshold Device (ITD), and venous occlusion thigh cuffs. Development of novel equipment that can indicate the reversal and maintenance of fluid shifts is also part of this approach.
Target for Closure
A laboratory-validated mechanical countermeasure that reverses fluid shifts.
Risk Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
You are here! Gap SANS-301: Laboratory development of mechanical countermeasures.

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